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2,4,6-三羥基苯乙酮 |
| CAS No.: |
480-66-0 |
| 分子式： |
C8H8O4.H2O |
| 分子量： |
186.16 |
| 備注： |
中文名稱2,4,6-三羥基苯乙酮中文同義詞2,4,6-三羥基苯乙酮，水合;2’,4’,6’-三羥基苯乙酮一水合物;2’,4’,6’-三羥基苯乙酮水合物;2,4,6-三羥基苯乙酮;6-三羥基苯乙酮;2,4,6-三羥基苯乙酮一水;苯乙酮,2’,4’,6’-三羥基-;三羥基苯乙酮一水合物英文名稱2’,4’,6’-Trihydroxyacetophenonemonohydrate英文同義詞2’,4’,6’-Trihydroxyacetophenonemonohydrate;2-Acetylphloroglucinolhydrate;Phloroacetophenonemonohydrate;THAP;2’,4’,6’-Trihydroxyacetophenone(monohydrate/anhydrous);2’,4’,6’-Trihydroxyacetophenonehydrate,98+%;1-(2,4,6-TRIHYDROXYPHENYL)-ETHANONE;2’,4’,6’-TRIHYDROXYACETOPHENONECAS號480-66-0分子式C8H8O4分子量168.15EINECS號207-556-5相關類別微生物代謝物;通用試劑;醫(yī)藥中間體;有機砌塊;中間體;其它有機金屬化合物;酮;小分子抑制劑;小分子抑制劑，天然產物;醇類及衍生物;羰基化合物;有機化工原料;活性分子;AlcoholsandDerivatives;CarbonylCompounds;AromaticAcetophenones&Derivatives(substituted);AnalyticalChemistry;MassSpectrometry;MatrixMaterials(MALDI-TOF-MS);Aromatics;Intermediates&FineChemicals;Pharmaceuticals;BuildingBlocks;C7toC8;ChemicalSynthesis;Ketones;OrganicBuildingBlocks;Inhibitors;其它酚類;醫(yī)藥原料;化工原料;合成材料中間體;中間體-有機中間體;化學試劑;對照品Mol文件480-66-0.mol結構式2,4,6-三羥基苯乙酮性質熔點219-221°C(lit.)沸點257.07°C(roughestimate)密度1.3037(roughestimate)折射率1.5090(estimate)儲存條件Storebelow+3Chemicalbook0°C.溶解度可溶于DMSO（少量）、乙醇（少量）、甲醇（少量）、水（非常少量，酸度系數(shù)(pKa)7.76±0.23(Predicted)形態(tài)粉末顏色淺黃色水溶解性Solubleinwater.BRN1911197穩(wěn)定性在建議的儲存條件下穩(wěn)定。LogP1.472(est)CAS數(shù)據(jù)庫480-66-0(CASDataBaseReference)NIST化學物質信息Ethanone,1-(2,4,6-trihydroxyphenyl)-(480-66-0)EPA化學物質信息Ethanone,1-(2,4,6-trihydroxyphenyl)-(480-66-0)2,4,6-三羥基苯乙酮用途與合成方法生物活性Phloracetophenone(2,4,6-trihydroxyacetophenone)是多葉姜黃(CurcumacomosaRoxb)中苯乙酮糖苷的糖苷配基部分，具有降低膽固醇作用，能夠增強膽固醇7α-羥化酶(CYP7A1)的活性；Phloracetophenone通過Mrp2刺激膽汁分泌。靶點Cholesterol7α-hydroxylase,Mrp2體外研究Phloracetophenone(2,4,6-trihydroxyacetophenone)isacholesterol-loweringagent,enhancescholesterol7α-hydroxylase(CYP7A1)activity,andelevatesCYP7A1mRNAlevel.Phloracetophenone(1,2,and4μmol/min)immediatelyanddose-dependentlyincreasesbileacid-independentbileflowintheisolatedperfusedratliver.體內研究Phloracetophenone(2,4,6-trihydroxyacetophenone;125or250μmol/kg,intraduodenalinjection)showscholereticactivityrequiringmultidrugresistanceprotein-2(Mrp2)inrats.Phloracetophenone(40μmol/min)partiallypreventstheE2-17Ginducedcholestasis.化學性質微黃色結晶。熔點217-219℃。用途本品用于有機合成、醫(yī)藥中間體和合成新型抗氧劑黃烷酮等。 |
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