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5-脫氧-5-甲硫腺苷 |
| CAS No.: |
2457-80-9 |
| 分子式： |
C11H15N5O3S |
| 分子量： |
297.33 |
| 備注： |
中文名稱5-脫氧-5-甲硫腺苷中文同義詞5’-甲硫腺苷;5’-脫氧-5’-硫代甲基酰苷;5-脫氧-5-甲硫腺苷;5ˊ-脫氧-5ˊ-甲硫基腺苷;甲硫腺苷;5′-脫氧-5′-腺苷;5-脫氧-5-甲硫腺苷(5’-脫氧-5’-硫代甲基酰苷、5ˊ-脫氧-5ˊ-甲硫基腺苷);甲硫腺苷對照品英文名稱5’-DEOXY-5’-METHYLTHIOADENOSINE英文同義詞2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol;7-(5-Methylthio-5-deoxy-D-ribofuranosyl)-7H-purine-6-amine;7-[Tetrahydro-3α,4α-dihydroxy-5β-(methylthiomethyl)furan-2-yl]-7H-purin-6-amine;5’-S-Methyl-5’-thioadesine;5’-Deoxy-5’-(methylthio)adenosine,98%;1-(6-AMino-9H-purin;5’-Deoxy(Methylthio)adenosine;NSC335422CAS號2457-80-9分子式C11H15N5O3S分子量297.33EINECS號相關類別中藥對照品;生物堿;化工原料;BiochemicalsandReagents;NucleosideAnalogs;Nucleosides,Nucleotides,OligonucleotidesMol文件2457-80-9.mol結構式5-脫氧-5-甲硫腺苷性質熔點210-213°C(dec.)沸點642.7±65.0°C(Predicted)密度1.85±0.1g/cm3(Predicted)儲存條件-20°C溶解度DMF（Chemicalbook少量）、DMSO（少量）、甲醇（少量）酸度系數(pKa)13.10±0.70(Predicted)形態(tài)白色固體顏色白色至類白色BRN424205-脫氧-5-甲硫腺苷用途與合成方法簡介5-脫氧-5-甲硫腺苷是一種C-5’的羥基被甲硫基（甲硫基）取代的腺苷，可用作抑制劑。生物活性5’-Methylthioadenosine是由S-腺苷酸產生的，有強效的抑制作用。靶點HumanEndogenousMetabolite體外研究5’-Methylthioadenosine(MTA)canaffectcellularprocessesinmanyways.5’-Methylthioadenosinehasbeenshowntoinfluencenumerouscriticalresponsesofthecellincludingregulationofgeneexpression,proliferation,differentiationandapoptosis.Althoughmostoftheseresponseshavebeenobservedatthepharmacologicallevel,theirspecificitymakesittemptingtospeculatethatendogenous5’-Methylthioadenosinecouldplayaregulatoryroleinthecell.Finally,observationscarriedoutinmodelsofliverdamageandcancerdemonstrateatherapeuticpotentialfor5’-Methylthioadenosinethatdeservesfurtherconsideration[1]. |
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