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衣霉素 |
| CAS No.: |
11089-65-9 |
| 分子式： |
C37H60N4O16 |
| 分子量： |
816.89 |
| 備注： |
中文名稱衣霉素中文同義詞衣霉素復合物;衣霉素來源于鏈霉菌屬;TUNICAMYCINFROMSTREPTOMYCESSP.來源于鏈霉菌屬;衣霉素(鏈霉菌屬);TUNICAMYCIN衣霉素;鏈病毒菌素;源于STREPTOMYCESLYSOSUPERFIUSNOV.SP.的鏈病毒菌素;衣霉素英文名稱TUNICAMYCIN英文同義詞Aids010655;Aids-010655;Nsc177382;TunicaMycinfroMStreptoMyceslysosuperficus;TunicaMycincoMplex;InSolution?Tunicamycin,;TUNICAMYCIN,STREPTOMYCESIYSOSUPERFICUS;TUNICAMYCIN,STREPTOMYCESLYSOSUPERFICUSCAS號11089-65-9分子式C37H60N4O16分子量816.89EINECS號601-012-4相關類別微生物代謝物;細胞信號和神經生物學;細胞生物學;抗生素;抗生素及抗病毒;抗生素、生物堿;生化試劑;對照品;化合物;化工原料;試劑盒-細胞分析試劑盒;小分子;NucleosidesMore...Close...;Antibacterial;Antibiotics;AntibioticsAto;AntibioticsbyApplication;AntibioticsT-ZAntibiotics;AntifungalAntibiotics;AntineoplasticandImmunosuppressiveAntibioticsAntibiotics;AntiviralAntibiotics;ChemicalStructureClass;InterfereswithProteinSynthesisSpectrumofActivity;L-ZAntibiotics;MechanismofAction;SpectrumofActivity;Signalling;antibioticMol文件11089-65-9.mol結構式衣霉素性質熔點234-235℃(decomposition)比旋光度D20+52°(c=0.5inpyridine)閃點87℃儲存條件2-8°C溶解度溶于甲醇、乙醇、DMSO或DMF形態(tài)白色至類白色固體顏色白色敏感性Moisture&LightSensitiveBRN6888090穩(wěn)定性自購買之日起2年內保持穩(wěn)定。DMSO或乙醇溶液可在-20°C下保存長達1個月。InChIKeyYJQCOFNZVFGCAF-WPChemicalbookTOCQRYSA-NEPA化學物質信息Tunicamycin(11089-65-9)衣霉素用途與合成方法生物活性Tunicamycin是一種同源核苷抗生素的混合物,可抑制N-糖基化并阻斷GlcNAc磷酸轉移酶(GPT)。Tunicamycin引起細胞內質網(wǎng)(ER)中未折疊蛋白的積累并誘導ER應激，并導致DNA合成受阻和G1期細胞周期停滯。Tunicamycin可抑制革蘭氏陽性細菌，酵母，真菌和病毒，并具有抗癌活性。Tunicamycin增加宮頸癌細胞中外泌體的釋放。體外研究Tunicamycin(2μg/mL;24hours;CD44+/CD24-andoriginalMCF7cells)treatmentincreasesthesplicedXBP-1,ATF6nucleartranslocationlevelandCHOPproteinexpressioninCD44+/CD24-andoriginalMCF7cells.Tunicamycin-inducedERstresssuppressesCD44+/CD24-phenotypecellsubpopulationandinvitroinvasionandacceleratestumorosphoreformation.UndereffectofTunicamycin,theresultsshowthatinhibitedinvasion,increasedcelldeath,suppressedproliferationandreducedmigrationintheCD44+/CD24-andCD44+/CD24-richMCF7cellculture.WesternBlotAnalysisCellLine:CD44+/CD24-andoriginalMCF7cells[1]Concentration:2μg/mLIncubationTime:24hoursResult:IncreasedlevelofsplicedXBP-1,ATF6nucleartranslocationandCHOPproteinexpressionaredetectedinCD44+/CD24-andoriginalMCF7cells.體內研究Tunicamycin(0.1mg/kgor0.5mg/kg)treatmentdramaticallysuppressestumorgrowthintheCD133+/-MHCC97Lcellsxenograftmodel(BALB/c(nu/nu)mice). |
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